Kalule has been involved in teaching, research, and community outreach as a Makerere University academic member of staff since February 2007. He is currently pursuing a Master’s of Medicine degree in Microbiology at Makerere University's Medical School in Kampala and will begin research in Immunology of neglected diseases in Uganda in 2009. In May 2007, he was trained in management of Avian Influenza by the National Task Force on Avian Influenza.
As part of his duties at the university, he teaches Immunology to undergraduate students and is also part of the Faculty of Veterinary Medicine Gender Committee.
During Kalule's first degree, he carried out research aimed at livelihood enhancement of dwellers of peri-urban Kampala and the evaluation of selected management parameters affecting small scale commercial poultry farmers; and during this research he interfaced extensively with peri-urban low income earners.
While in Ireland, Kalule trained in the Immunology laboratories at the National University of Ireland, Maynooth, and given training in the following techniques:
- Cell culture
- Plasmid cloning
- Water microbiology
- Food microbiology
- H and E staining
- Flow cytometry
- PCNA staining
- Agarose gel electrophoresis
- Clinical microbiology
Kalule was also heavily involved in the CDPC Education Outreach lecture series, where he toured the country with the CDPC's Education Officer Joe Clowry, giving presentations to second-level students on HIV/AIDS and other diseases of poverty.
Kalule spent a week training in University Hospital Galway, where he was given training in salmonella serotyping, phage typing, pulse field gel electrophoresis and public health microbiology. During his time off, Kalule visited Dublin and spent a weekend in Southampton, England, where he visited family friends.